Under leadership of John MacMillan, the UC Santa Cruz, Office of Research has primary responsibility for research policy, planning and administration of the UC Santa Cruz research enterprise. VCR MacMillan’s current research lab and prolific career has focused predominantly on the therapeutic areas of infectious disease and oncology, combining phenotypic screening, isolation and mechanism of action studies towards the discovery of more than 100 new natural products. This work has led to establishment of the Center for High Functional Annotation of Natural Products (HIFAN), which is a multi-institutional center funded by the NIH to study the mechanism of botanicals and natural products. His work in the area of oncology has yielded a first in-class inhibitor of Hypoxia Inducible Factor 2 (HIF-2) that is currently undergoing clinical trials for the treatment of renal cell carcinoma.
Dr. MacMillan holds a Ph.D. in Chemistry from the University of California, Davis. Prior to moving to the University of California, Santa Cruz he was on faculty at the University of Texas Southwestern Medical Center.